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Why Should You Take Mangosteen?
Mangosteen Fruit Juice is formulated and sold as a dietary nutritional supplement. The product is derived primarily from the puree of the whole mangosteen fruit. That's right... the pulp, rind and seed. So, what's the excitement all about drinking mangosteen fruit juice?
It is now a well established scientific fact that the mangosteen fruit (garcinia cambogia) is one of the best natural sources of naturally occurring xanthones, potent antioxidants. Xanthones research by scientists for many years have demonstrated the enormous health benefits to humans that are well documented in the scientific literature. The mangosteen fruit (aka Queen of Fruits) itself has been used for centuries by local natives in Asia to treat numerous physical ailments and diseases.
So, what are xanthones? Xanthones are a class of over 200 chemical compounds that are similar to vitamins. They can be made in the laboratory (synthetic) or extracted from plants. Mangosteen fruit juice contains intact xanthones, since the whole fruit is used for formulation. Nothing is extracted from the mangosteen fruit nor synthetic xanthones added to the formulation. This is critical to preserve the integrity of the xanthones, since synthesis or extraction can cause some xanthones to lose their antioxidant potencies.
There are at least 40 xanthones indentified in the mangosteen fruit (garcinia cambogia). Two of the most powerful xanthones occur in the mangosteen fruit, especially it's rind. These powerful antioxidants are alpha mangostin and gamma mangostin. Numerous scientific studies were done with these two xanthones. You are probably wondering what are the health benefits of the mangosteen fruit juice and its powerful xanthones. There are literally scores of mangosteen fruit juice health benefits users swear by. You will have to try the mangosteen fruit juice for yourself. I know there are many folks who are experiencing incredible mangosteen health benefits. I use it everyday in my orange juice and the energy and libido boost are real for me. However, the bottom line is mangosteen fruit xanthones research to back up a claim. If the research is there, you've got a winner.
Xanthone Research Summary
As a board-certified MD with more than 25 years clinical and academic experience, I do not accept the claims of holistic products easily. There are a number of holistic health products on the market, with precious little research to back up their claims. The reason that I chose to present mangosteen to my clients is revealed below. There are literally dozens of research articles to support the biological activity of xanthones and mangosteen against a host of illnesses and conditions that plague mankind. The scientist in me demands the rigor of the following studies. Take a look.
1) Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004 Jan;90(1):161-6. Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N.Department of Microbiology, Faculty of Pharmacy, Mahidol University, Sri Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand. pypmk@mahidol.ac.th These investigators found that an extract from the pericarp of the mangosteen fruit inhibited the growth of breast cancer cells. They also showed that the extract had potent antioxidant and cancer cell death properties. They concluded that the extract from the pericarp of the mangosteen fruit has potential for chemoprevention. 2) Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y. Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kmatsumoto@giib.or.jp These authors examined the effects of six xanthones extracted from the pericarps of the mangosteen fruit, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin (a xanthone) showed the most potent ability to cause the cancer cells death. 3) Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9. Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, Suksamrarn A. Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand. sunit@swu.ac.th Xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, mangosteen fruit, were tested for their antituberculosis potential. The investigators found alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis (TB). 4) Garcinone E, a xanthone derivative, has potent cytotoxic effect against the patocellular carcinoma cell lines. Planta Med. 2002 Nov;68(11):975-9. Ho CK, Huang YL, Chen CC. Department of Medical Research & Education, Veterans General Hospital, Taipei, ROC. Treatment of hepatocellular carcinomas (liver cancer) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs. The investigators extracted and purified 6 xanthone compounds from the rinds (peel) of the fruit of Garcinia mangostana, mangosteen fruit. The investigators tested this extract on 14 different human liver cancer cell lines. Several chemotherapeutic agents (drugs) were included in the study for comparison. The results showed that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect (kill cells) on all liver cancer cell lines as well as on the other gastric and lung cancer cell lines included in the screen. The investigators suggested that garcinone E may be potentially useful for the treatment of certain types of cancer. 5) Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull. 2002 Sep;25(9):1137-41. Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. The fruit hull of mangosteen, Garcinia mangostana L., mangosteen fruit, has been used as a Thai indigenous medicine for many years. However, its mechanism of action as a medicine has not been elucidated. The present study was undertaken to examine the effects of mangosteen fruit extracts on histamine release and prostaglandin E2 synthesis. The investigators found the mangosteen fruit extract strongly inhibited histamine release and prostaglandin E2 synthesis. This has great importance in preventing allergies. 6) Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem Pharmacol. 2002 Jan 1;63(1):73-9. Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, 980-8578, Sendai, Japan. The fruit hull of mangosteen fruit, Garcinia mangostana L., has been used for many years as a medicine for treatment of skin infection, wounds, and diarrhea in Southeast Asia. In the present study, the investigators studied the effect of gamma-mangostin, a xanthone contained in the mangosteen fruit, and showed it had a potent inhibitory activity of prostaglandin E2 (PGE2) release. 7) Immunopharmacological activity of polysaccharide from the pericarp of mangosteen garcinia: phagocytic intracellular killing activities. J Med Assoc Thai. 1997 Sep;80 Suppl 1:S149-54. Chanarat P, Chanarat N, Fujihara M, Nagumo T. Department of Clinical Microscopy, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand. Polysaccharides from the pericarps of mangosteen, Garcinia mangostana Linn., mangosteen fruit, were extracted from the dried ground pericarps of the mangosteen fruit. The results showed that the number of S. enteritidis (bacteria) in cultured monocyte with extract of the pericarp of the mangosteen fruit was killed. This paper showed that polysaccharides in the extract can stimulate phagocytic cells to kill intracellular bacteria (S. enteritidis). 8) Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med. 1996 Oct;62(5):471-2. Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y. The investigators studied an extract of the fruit hull of Mangosteen, Garcinia mangostana L., mangosteen fruit. On the basis of pharmacological data, they determined that alpha-mangostin and gamma-mangostin (xanthones in mangostana) are a histaminergic and a serotonergic receptor blocking agent, respectively. That is, they have the ability to prevent allergies and inflammation. 9) Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Free Radic Res. 2000 Nov;33(5):643-59. Mahabusarakam W, Proudfoot J, Taylor W, Croft K. Chemistry Department, Prince of Songkla University, Hat Yai, Thailand. Oxidative damage is thought to play a critical role in cardiovascular and other chronic diseases. This has led to considerable interest in the antioxidant activity of dietary compounds. The researchers have previously shown that the xanthone, mangostin (found in mangosteen fruit), can inhibit the oxidation of LDL, low density lipoprotein (bad cholesterol). Researchers studied more xanthone derived compounds and found enhanced antioxidant activities. Note: If the oxidation of LDL cholesterol can be prevented or inhibited, then the LDL-cholesterol cannot exert its “bad” effect and cause heart disease. 10) Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med. 1998 Mar;64(2):97-109. Vlietinck AJ, De Bruyne T, Apers S, Pieters LA. Department of Pharmaceutical Sciences, University of Antwerp (UA), Belgium. vlietink@uta.ua.ac.be The investigators showed many compounds of plant origin have been identified that inhibit different stages in the replication cycle of human immunodeficiency virus (HIV). Among these compounds, the xanthone mangostin, derived from mangosteen fruit, was shown to inhibit the replication cycle of HIV. 11) Novel types of receptor antagonists from the medicinal plant Garcinia mangostana [Article in Japanese] Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:153P-158P. Furukawa K, Chairungsrilerd N, Ohta T, Nozoe S, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. Here the researchers used a crude extract of the fruit hull of Garcinia mangostana L, mangosteen fruit. On the basis of physicochemical data, the active substances were identified as alpha-mangostin and gamma-mangostin in the crude extract. The researchers found that alpha-Mangostin and gamma-mangostin may become novel types of lead compounds for histamine and serotonin receptor antagonists (fight allergies and inflammation). 12) Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist. Eur J Pharmacol. 1996 Oct 31;314(3):351-6. Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. Researchers found that alpha-mangostin (found in the mangosteen fruit) blocked the binding of histamine to its receptors (fight allergies and inflammation). 13) Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus. J Pharm Pharmacol. 1996 Aug;48(8):861-5. Iinuma M, Tosa H, Tanaka T, Asai F, Kobayashi Y, Shimano R, Miyauchi K. Department of Pharmacognosy, Gifu Pharmaceutical University, Japan. The investigators showed that extracts of Garcinia mangostana, mangosteen fruit, possessed inhibitory effects against the growth of S. aureus (staph bacteria). The strong in-vitro antibacterial activity of xanthone derivatives against both methicillin-resistant and methicillin sensitive Staphylococcus aureus suggests the compounds might find wide pharmaceutical use. 14) Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med. 1996 Aug;62(4):381-2. Chen SX, Wan M, Loh BN. The investigators found that an extract of Garcinia mangostana L., mangosteen fruit, showed potent inhibitory activity against HIV-1 protease which affects the replication of HIV. 15) Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic Res. 1995 Aug;23(2):175-84. Williams P, Ongsakul M, Proudfoot J, Croft K, Beilin L. University of Western Australia, Department of Medicine, Royal Perth Hospital, Australia. The oxidation of low density lipoprotein (LDL) may play an important role in atherosclerosis. The researchers investigated the possible antioxidant effects of mangostin, isolated from Garcinia mangostana (found in mangosteen fruit), on the oxidation of human LDL (bad cholesterol). From these results, they concluded that mangostin is acting as a free radical scavenger (“mop up” sponge) to protect the LDL from oxidative damage in this in vitro system. In other words, it a potent antioxdiant. 16) Alpha-mangostin induces Ca(2+)-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells. J Pharmacol Sci. 2004 May;95(1):33-40. Sato A, Fujiwara H, Oku H, Ishiguro K, Ohizumi Y. Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. The researchers investigated the cell death effects of eight xanthones on pheochromocytoma (cancer) cells. Among these compounds, alpha-mangostin, from the fruit hull of Garcinia mangostana L. (mangosteen fruit), had the most potent effect with apoptosis (death) of these cells. 17) Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors. Bioorg Med Chem. 2003 Nov 17;11(23):5171-7. Jiang DJ, Hu GY, Jiang JL, Xiang HL, Deng HW, Li YJ. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. The researchers found that xanthone preserved endothelial cells inhibited the increased adhesion of monocytes to endothelial cells induced by oxidized LDL. This is especially important in preventing plaque formation and the subsequent blockage of arteries and heart disease. 18) Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro. Bioorg Med Chem. 2002 Dec;10(12):3725-30. Pedro M, Cerqueira F, Sousa ME, Nascimento MS, Pinto M. Centro de Estudos de Quimica Organica, Fitoquimica e Farmacologia da Universidade do Porto, Faculdade de Farmacia, Porto, Portugal. madalena@ff.up.pt Twenty-seven xanthones were assessed for their capacity to inhibit the in vitro the growth of three human cancer cell lines, (breast cancer, renal cancer, melanoma). Inhibition of growth of these cancer cell lines depended on the type of xanthone used in the study. 19) Xanthones from the green fruit hulls of Garcinia mangostana. J Nat Prod. 2002 May;65(5):761-3. Suksamrarn S, Suwannapoch N, Ratananukul P, Aroonlerk N, Suksamrarn A. Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand. sunit@psm.swu.ac.th Researchers isolated three new xanthones, mangostenol (1), mangostenone A (2), and mangostenone B (3), from the green fruit hulls of Garcinia mangostana, mangosteen fruit. NB: There are about 200 naturally occurring xanthones. The mangosteen fruit (mangostana garcina) possesses 40 of these xanthones with even more being discovered via research. 20) Antihypertensive and vasorelaxing activities of synthetic xanthone derivatives. Bioorg Med Chem. 2002 Mar;10(3):567-72. Wang LW, Kang JJ, Chen IJ, Teng CM, Lin CN. School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, ROC. The researchers studied a series of xanthones and related compounds. The antihypertensive (against high blood pressure) and vasorelaxing (relaxing of the blood vessels to prevent high blood pressure) activity of compounds on cardiovascular system was evaluated. All the compounds tested exhibited effective hypotensive (lower blood pressure) activity in anesthetized rats. 21) Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine. 2001 Mar;8(2):85-7. Miura T, Ichiki H, Hashimoto I, Iwamoto N, Kato M, Kubo M, Ishihara E, Komatsu Y, Okada M, Ishida T, Tanigawa K. Suzuka University of Medical Science, Mie, Japan. Mangiferin, a xanthone, lowered the blood glucose (sugar) level in type II diabetic mice. From these findings, it seems likely that mangiferin exerts its antidiabetic activity by decreasing insulin resistance. 22) Antiplatelets activity of some xanthone derivatives. Acta Pol Pharm. 1999 Jul-Aug;56(4):319-24. Rajtar G, Zolkowska D, Kleinrok Z, Marona H. Department of Pharmacology and Toxicology, Medical University School, Lublin, Poland. Researchers studied the effects of twelve xanthone derived compounds on platelet aggregation. They found five of them inhibited thrombin-induced platelet aggregation (clot formation). 23) Chiral 2-amino-1-butanol xanthone derivatives as potential antiarrhythmic and hypotensive agents. Acta Pol Pharm. 1999 Jan-Feb;56(1):87-90. Librowski T, Czarnecki R, Jastrzebska M. Department of Pharmacodynamics, Collegium Medicum Jagiellonian University, Krakow, Poland. Cancer Lett. 1998 Oct 23;132(1-2):113-7. Xanthones as inhibitors of Epstein-Barr virus activation. Ito C, Itoigawa M, Furukawa H, Rao KS, Enjo F, Bu P, Takayasu J, Tokuda H, Nishino H. Faculty of Pharmacy, Meijo University, Nagoya, Japan. Researchers screened 20 xanthones and found that 3 of them to have valuable anti-tumor (against cancer) activities. 24) Synthesis and anticonvulsant effects of some aminoalkanolic derivatives of xanthone. Pharmazie. 1998 Oct;53(10):672-6. Marona H. Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Krakow, Poland. Researchers studied compounds derived from xanthone for anticonvulsant activities. They found several xanthone derived compounds to be active in anticonvulsant tests. 25) Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336(1):23-8. Cheng YW, Kang JJ. Institute of Toxicology, College of Medicine, National Taiwan University, Taipei. The researchers showed vasorelaxation (relaxing of blood vessels) activity of the xanthones studied. 26) Xanthones as antimalarial agents; studies of a possible mode of action. FEBS Lett. 1997 Jun 2;409(1):67-73. Ignatushchenko MV, Winter RW, Bachinger HP, Hinrichs DJ, Riscoe MK. Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201, USA. Researchers showed potent antimalarial activities for the xanthones studied. 27) Synthesis and antithrombotic effect of xanthone derivatives. J Pharm Pharmacol. 1996 Sep;48(9):887-90. Lin CN, Hsieh HK, Liou SJ, Ko HH, Lin HC, Chung MI, Ko FN, Liu HW, Teng CM. School of Pharmacy, Department of Internal Medicine, Kaohsiung Medical College, Taiwan, R.O.C. Researchers studied several xanthone derived compounds and found them to possess potent antithrombotic (anti clotting) activities. 28) Xanthone derivatives as potential anti-cancer drugs. J Pharm Pharmacol. 1996 May;48(5):539-44. Lin CN, Liou SJ, Lee TH, Chuang YC, Won SJ. School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China. Researchers showed xanthone derived compounds to have potent antitumor activities against human cancer cells. 29) Synthesis and anti-inflammatory effects of xanthone derivatives. J Pharm Pharmacol. 1996 May;48(5):532-8. Lin CN, Chung MI, Liou SJ, Lee TH, Wang JP. School of Pharmacy, Kaohsiung Medical College, Taiwan, R.O.C. The researchers studied 18 xanthone derived compounds and found that some of these compounds possessed strong anti-inflammatory properties. 30) Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases. Biochem Pharmacol. 1994 Jun 15;47(12):2307-10. Thull U, Testa B. Institut de Chimie Therapeutique, Ecole de Pharmacie, Universite de Lausanne, Switzerland. Of several compounds studied, xanthone emerged as a potent monoamine oxidase inhibitor. 31) Gamma-pyrone compounds as potential anti-cancer drugs. J Pharm Pharmacol. 1993 Sep;45(9):791-4. Liou SS, Shieh WL, Cheng TH, Won SJ, Lin CN. Natural Products Research Center, Kaohsiung Medical College, Taiwan, Republic of China. Researchers studied several compounds and found xanthones with enhanced anti-tumor activity against human cancer cell lines.
One of the most important aspects of mangosteen is its ability to absorb free radicals from the body. This is measured as oxygen radical absorbance capacity. M. Gibson MD Q: Have you ever heard the term ORAC? What is it? What does it mean for the foods I eat? A: ORAC stands for Oxygen Radical Absorbance Capacity. This is just a fancy way of measuring the antioxidant “strength” of foods. The strength or ability to “mop up” damaging free oxygen radicals. Q: In the name ORAC are the words ‘oxygen radical’. What are oxygen radicals? Why do we want to absorb them? A: Oxygen radicals are products (chemicals) of chemical reactions that take place in our bodies. They are a part of your biochemistry and you cannot avoid them. These oxygen free radicals have been implicated in many disease processes in our bodies. They damage our cells by a process called oxidation. No tissue, organ or gland is spared of the damaging effects of these free radicals. If our bodies can absorb and stop these oxygen free radicals before they do damage, they won’t hurt us. Q: What are some of the “bad effects” of oxygen radicals? A: If you allow the oxygen radicals to roam freely in your bodies, sooner or later they’ll attack every cell, tissue, and organ to produce … heart disease (especially, blockages leading to heart attacks) … wrinkling of the skin … cancers … infections … hormonal imbalances ... and many, many more conditions Q: Is there anything I can do to stop the oxygen radical damage from happening in my body? A: YES! We’ve got to find a “sponge” that mops up these oxygen radicals and take them out of commission. The easiest and most reliable way to do this is to introduce chemicals in the body to bind (react) with the oxygen radicals and render them inactive. That’s the role of antioxidants. They are the “mop up sponges” of the oxygen radicals. The stronger the antioxidants, the better the “mop up” job. Q: So, what are some of these “mop up sponges” or antioxidants? A: Usually plant foods such as fruits, vegetables, whole grains, beans, and nuts are the best sources of antioxidants. Brightly colored fruits and vegetables have the highest ORAC scores. Q: How does XanGo rank as an antioxidant or “mop up sponge”? A: I’ve listed a table of ORAC values (measure of oxygen radical “mop up” strength) below. Take a look at the value for XanGo. Just 1 oz. has 21,000 ORAC units. Tahitian Noni Juice is not even close (1,506). You will need to eat bucketfuls of fruits and vegetables and still not get to the ORAC value XanGo mangosteen fruit juice delivers with just one ounce of this beverage.
[1] Agricultural Research, November 1996, pp. 4-8. SEE ORAC CHART @ The Watsons approach to Optimal Health & Longevity @: http://optimalhealth.cia.com.au/OracLevels.htm [2] Ronald Prior, et al., Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts, Boston, Mass., in J. Agric. Food Chem. 1998; 46: 2686-2693 & Hort Science 1999. [3] J Agric Food Chem 2001 Nov; 49(11): 5165-70.
Taking 2-3 ounces per day of Xango can and often does have long lasting benefits for your health. The effects often take 2-3 months to surface so one or two bottles are not going to do much for you. The following is a summary of the health benefits of the xanthones contained in Xango.
Xango Usage Guidelines Refrigeration of open bottles is recommended and enhances the taste, however, there is no reason for concern if the juice is left at room temperature for up to two days. Unopened bottles need not be refrigerated but should be stored at room temperature. SHAKE PRODUCT BEFORE USE * The clear plastic piece inside the cap should be placed on the peg in the cap if it remains on the glass bottle when opened. This prevents leakage when you shake the juice. * Use an accurate measuring device for portioning and take regularly. * Best to take with meals, if possible. * Dividing the portion into three times a day is much more effective than taking it one or two times a day. Portioning Recommendations Children & Infants *Please note: after they have been introduced to fruit juice. Adults Minor Problems Major Problems Cancer This is a non-toxic product, and there is no lethal portion. However, children may often achieve the benefits at lower portions. Dividing the portions into three times a day is much more effective than taking it one or two times a day due to the half life of mangosteen being four to six hours. Flare-ups of any diseases should be treated with increased intake until improvement occurs. Doubling or tripling the portion is recommended. Ordering information:
To receive Xango at the wholesale price click here: For more information please click here.
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Case (4 bottles)- $140.00 shipping is $20.00
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